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| Pereira,Kércia Regina Santos Gomes; Açucena,Maria Kadja Meneses Torres; Villarim Neto,Arthur; Rêgo,Amália Cínthia Meneses; Bernardo-Filho,Mário; Azevedo,Ítalo Medeiros; Araújo Filho,Irami; Medeiros,Aldo Cunha. |
| Drugs and surgery can interfere with the biodistribution of radiopharmaceuticals and data about the effect of splenectomy on the metabolism of phytate-Tc-99m are scarce. This study aimed at evaluating the interference of splenectomy on phytate-Tc-99m biodistribution and liver function in rats. The SP group rats (n=6) underwent splenectomy. In group C (control) the animals were not operated on. After 15 days, all rats were injected with 0.1mL of Tc-99m-phytate via orbital plexus (0.66MBq). After 30 minutes, liver samples were harvested, weighed and the percentage of radioactivity per gram (%ATI/g) was determined by a Wizard Perkin-Elme gama counter. The ATI%/g in splenectomized rats (0.99±0.02) was significantly higher than in controls (0.4±0.02),... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Splenectomy; Sodium phytate; Biodistribution; Liver. |
| Ano: 2008 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132008000700033 |
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| Açucena,Maria Kadja Meneses Torres; Pereira,Kércia Regina Santos Gomes; Villarim Neto,Arthur; Rêgo,Amália Cínthia Meneses; Bernardo-Filho,Mario; Azevedo,Ítalo Medeiros; Araújo Filho,Irami; Medeiros,Aldo Cunha. |
| This study aimed to evaluate if the splenectomy alters the biodistribution of 99mTc-DMSA and renal function in Wistar rats. The animals were separated in the groups: splenectomy (n = 6) and control (n = 6). After splenectomy (15 days), the administration of 0.1ml of 99mTc-DMSA IV (0.48 MBq) was carried out. Thirty minutes later, kidney, heart, lung, thyroid, stomach, bladder and femur and samples of blood were isolated. The organs were weighed, counted and the percentage of radioactivity /g (%ATI/g) determined. Serum urea and creatinine, hematocrit, leukocytes and platelets were measured. Statistics by t test (p<0.05) was done. There was a significant reduction in %ATI/g in kidney and blood (p<0.05) of splenectomized animals, a significant increase... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Splenectomy; Biodistribution; Technetium; Rats. |
| Ano: 2008 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132008000700032 |
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